ALZHEIMER DISEASE AND ACETYLCHOLINESTERASE INHIBITORS
نویسندگان
چکیده
منابع مشابه
Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors.
Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for example its role in regulation of apoptosis. Cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathoge...
متن کامل[Use of acetylcholinesterase inhibitors and memantine in Alzheimer-type dementia].
BACKGROUND The therapeutic options to treat Alzheimer-type dementia (ATD) in recent years, have made it increasingly necessary to become familiar with the employment pattern of these new medicinal products. METHODS A cross-sectional observational study of the population with ATD treated with acetylcholinesterase inhibitors and/or memantine in the Gallician Health Service. Databases were compi...
متن کاملNew Acetylcholinesterase Inhibitors for Alzheimer's Disease
Acetylcholinesterase (AChE) remains a highly viable target for the symptomatic improvement in Alzheimer's disease (AD) because cholinergic deficit is a consistent and early finding in AD. The treatment approach of inhibiting peripheral AchE for myasthenia gravis had effectively proven that AchE inhibition was a reachable therapeutic target. Subsequently tacrine, donepezil, rivastigmine, and gal...
متن کامل[Acetylcholinesterase inhibitors for treatment of Alzheimer's disease].
Alzheimer's disease (AD) is a neurodegenerative disorder, and is the commonest cause of dementia. Acetylcholinesterase inhibitors (AChEIs) were developed under the cholinergic hypothesis of AD. Therapeutic strategies with these drugs aimed to enhance cholinergic neurotransmission in specific parts of the brain, and to improve the clinical symptoms of AD. Donepezil, galantamine and rivastigmine ...
متن کاملIsolation and characterization of acetylcholinesterase inhibitors from Piper longum L.
Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...
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ژورنال
عنوان ژورنال: Jurnal Kedokteran dan Kesehatan Indonesia
سال: 2009
ISSN: 2085-4145,2527-2950
DOI: 10.20885/jkki.vol7.iss5.art1